HTML5 elements like header, nav, main, and footer automatically carry landmark roles, and screen readers provide a dedicated shortcut for jumping between them, similar to a table of contents. A page with clear, correctly used landmarks lets an experienced screen reader user reach the main content in seconds rather than tabbing through the entire header first.
A common mistake is using multiple nav elements without distinguishing labels, which forces users to guess which navigation region is which when their screen reader lists several regions all announced simply as “navigation.”